Sebelipase alfa is a recombinant form of the enzyme lysosomal acid lipase that was approved in 2015 under the tradename Kanuma in the US and EU for the treatment of people with lysosomal acid lipase deficiency.
Restaurants in Kanuma
4.5 based on 62 reviews
Our guide informed us of a unique shrine and Gardens that seldom received tourists from America, and that it was good place to have lunch. We enjoyed both the shrine and the magnificent grounds complete with Waterfalls. Unfortunately the restaurant was closed but it was well worth the visit.
4.5 based on 394 reviews
This is a big emptied out underground stone quarry. As such, it's not nearly as interesting as natural caves can be, but is still kind of cool in an of itself (and is also, literally cool, at a constant 10º or so).
The place has been used for movies and events, so there are some created terraces etc. in the space that look neat.
I'm struggling to find more to say than "it was a big stone cavern." It's sort of interesting, but not worth making a huge diversion for.
4.5 based on 15 reviews
4 based on 6 reviews
The Kanuma Buttsuke Autumn Festival is a regular event held by Imamiya Shrine at various locations in the historic district. 23 Extravagant festival cars called chokoku-yatai (engraved floats) are paraded around the streets of Kanuma. On the first day, the chokoku-yatai are marched in and out of Imamiya Shrine, and after the citizen parade on the second day, the festival cars are split into four groups and depart from four different intersections, coming together at one intersection for the yatai soroihiki (gathering and presentation of floats). A highlight of the festival is the recital contest of the buttsuke - the traditional orchestra that announces the floats.
4 based on 128 reviews
The Heiwa Kannon-zo (Kannon Peace Statue) was interesting because it was carved into the stone. Prior to entering this area, you are mesmerized by the entrance way which looks like you are entering a mountain passage of stone. There is a staircase to the left and from there you can see the view of the Oya Temple behind the statue as well as the area in front (it is quite a climb up the stairs, so make sure you are hydrated and rest along the way if you get winded easily). Afterwards, I went to the temple and was awestruck by the 11,000 year old human remains and the statues carved into the wall. Photography is not allowed in the temple area that showcases the 1000 armed Oya Kannon goddess of mercy statue. Past this area is a small museum that houses the 11,000 year old human remains found at this site as well as the other artifacts from the excavation. Beyond this area there is are two area with the Bridges, the first one has the two statues of snakes (coiled and uncoiled). Some visit to give their donation and ask for blessings by rubbing the snake's head.
4.5 based on 3 reviews
鹿沼市役所近くの中心市街地にあります。国道293号線沿いなのですぐに見つかるでしょう。宇都宮藩の志士たちの影響を与えた儒者・鈴木石橋などの墓があります。鹿沼市街の歴史散歩のスタート地点によいでしょう。
3.5 based on 6 reviews
If you visit this shrine during the second weekend in October, you will think it's an amazing place. If you visit any other time of the year, you will think "meh, another shrine".
Hence my rating of "very good".
In October the shrine hosts the Kanuma Fall Festival and it's busy and crowded and filled to capacity with festival floats and teams that pull them.
Other times of the year, it's just an average main shrine.
4 based on 6 reviews
日光との境に近い鹿沼の秘境にある渓谷。渓谷に至る道は狭く、すれ違いも困難なほどですが、紅葉の時期に行くととてもきれいです。渓谷の上流には滝もありますので、それを目標の一つとして行ってみるとよいでしょう。
3.5 based on 6 reviews
鹿沼駅から徒歩20位歩いた場所にあります。屋台展示館は、有料(200円)です。
館内は、屋台が3台展示してあり、階段をのぼると、上の方まで見ることができます。掬翠園は、無料の庭園です。
3.5 based on 87 reviews
You will drop by here after visiting Oya stone Museum which is about 5 mins drive away. While the stature is certainly majestic, I find it difficult to visit this attraction just on its own. So do pair up with a visit to Oya stone Museum. There is a temple (fees apply) nearby which is the parking area where you can see more Buddha carvings in an enclosed cave and an exhibit of a mummified monk before Christ...
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